In(OTf)3/acid co-catalyzed hydration of 1-haloalkynes to α-halomethyl ketones

Add time:07/20/2019    Source:sciencedirect.com

A novel and efficient In(OTf)3 and HOAc cooperatively catalyzed hydration of 1-haloalkynes is described. This method provides ready access to α-chloromethyl ketones, α-bromomethyl ketones and α-iodomethyl ketones in moderate to high yields from simple, inexpensive starting materials. A broad substrate scope is achieved, and the reaction is compatible with various functional groups, including alkoxy, trifluoromethyl, halide, hydroxyl, cyclohexyl, and heterocyclic groups.

We also recommend Trading Suppliers and Manufacturers of 1-(5-BROMO-4-CHLORO-2-THIENYL)ETHANONE (cas 123418-66-6). Pls Click Website Link as below: cas 123418-66-6 suppliers

Prev:Catalyst-free and atom-economic synthesis of substituted 1-acetyl and 1-hydroxyl carbazoles
Next:Synthesis and SAR optimization of diketo acid pharmacophore for HCV NS5B polymerase inhibition)