The antiviral activity of Arbidol hydrochloride (cas 131707-23-8) against herpes simplex virus type II (HSV-2) in a mouse model of vaginitis

Add time:07/23/2019    Source:sciencedirect.com

ObjectiveHSV-2 infection has increased significantly in recent years, which is closely associated with cervical cancer and HIV infection. The lack of success in vaccine development and the emergence of drug resistance to commonly used drugs emphasize the urgent need for alternative antivirals against HSV-2 infection. Arbidol (ARB) has been demonstrated to be a broad spectrum antiviral drug that exhibits immunomodulatory properties that affect the HSV-2 life cycle. This study investigated the efficacy and mechanism of ARB against HSV-2 in vivo and in vitro to further explore the clinical application of ARB.

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