Recent progress on the iterative construction of 4-substituted-3-hydroxy benzoic acids from unsaturated aldehydes and dimethyl succinate

Add time:07/11/2019    Source:sciencedirect.com

An improvement of a known two step cyclization procedure, affording 4-aryl-3-hydroxy benzoic acid derivatives from 3-aryl-2,3-unsaturated aldehydes and dimethyl succinate, is described. The high versatility of the synthetic procedure is shown, as the aryl substituent can be a benzene or naphthalene moiety, or an heteroaromatic ring. It can be applied iteratively to prepare p,p'-oligophenyl derivatives.

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