Solid phase synthesis of oligonucleotides containing 3′-thiothymidine

Add time:07/20/2019    Source:sciencedirect.com

A 5′-O-monomethoxytritylthymidine-3′-S-thiophosphoramidite (3) has been used to prepare oligodeoxynucleotides containing 3′-thiothymidine on a solid phase support. The intermediate thiophosphites are most efficiently oxidised using tetrabutylammonium periodate.

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