Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines

Add time:07/20/2019    Source:sciencedirect.com

We have synthesized novel 2-O-substituted apomorphines with both different lengths of lipophilic alkyl chains and alkyl chains carrying free hydroxyl groups. Two bis-apomorphines formed as side products of the reactions with diols were isolated and characterized as well. The neuropharmacological profile of all these new compounds were investigated with respect to their binding affinities and activities to dopamine D2 and D1 receptors. The obtained data pointed to the fact that, in the examination of dopaminergic activities of 2-substituted apomorphines, the lipophilicity of the substituent is more important than its spatial parameters.

We also recommend Trading Suppliers and Manufacturers of 2-methoxyapomorphine (cas 126874-79-1). Pls Click Website Link as below: cas 126874-79-1 suppliers

Prev:Insight into the theoretical and experimental studies of 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone N(4)-methyl-N(4)- phenylthiosemicarbazone - A potential NLO material
Next:The Effects of Intravenous Naltrindole and Naltrindole 5′-Isothiocyanate on Sufentanil-Induced Respiratory Depression and Antinociception in Rats)