New facile synthesis of furan-2(3H)-ones and 2,3,5-trisubstituted furans via intramolecular Wittig reaction of acid anhydride

Add time:07/20/2019    Source:sciencedirect.com

A new facile preparation of furan-2(3H)-ones and 2,3,5-trisubstituted furans by a sequential O-acylation/Wittig(/O-acylation) reaction has been developed. The easily accessible 2-(triphenylphosphoranylidene)-succinic acid 1-ester 3 reacted with acid chloride produced furan-2(3H)-ones 4 in good yields in the presence of DMAP via sequential O-acylation and intramolecular Wittig reaction of acid anhydride. Subsequently, the 2,3,5-trisubstituted furans 5 were prepared from furan-2(3H)-ones 4 and diverse aryl chlorides in presence of triethylamine through further O-acylation.

We also recommend Trading Suppliers and Manufacturers of 2-(4-BROMOPHENYL)FURAN (cas 14297-34-8). Pls Click Website Link as below: cas 14297-34-8 suppliers

Prev:New synthesis of 1,2-Bismethylenecyclobutane (cas 14296-80-1)s by [2+2] cycloaddition reaction of 1,1-diphenyl-4,4-bis(trifluoromethyl)-butatriene with electron-rich alkenes
Next:Acid-promoted furan annulation and aromatization: An access to benzo[b]furan derivatives)