Straightforward preparation and use in oligodeoxynucleotide synthesis of 5′-O-(4,4′-dimethoxytrityl)-4-[S-(2-cyanoethyl)]-thiothymidine

Add time:07/20/2019    Source:sciencedirect.com

The title compound was prepared in four steps and 62% yield from thymidine. After incorporation into synthetic oligodeoxynucleotides, the S-(2-cyanoethyl) group was removed by treatment with DBU in CH3CN to give products containing 4-thiothymidine residues.

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