Development and in vitro evaluation of thiolated chitosan—Poly(methacrylic acid) nanoparticles as a local mucoadhesive delivery system

Add time:07/27/2019    Source:sciencedirect.com

The main objective of this study was to develop a local, oral mucoadhesive metronidazole benzoate (MET) delivery system that can be applied and removed by the patient for the treatment of periodontal diseases. The results of present study revealed that the retention time of MET at its absorption site could be increased by formulating it into nanoparticles using thiolated chitosan (TCS)–poly(methacrylic acid) (PMAA). The nanoparticles of MET prepared from TCS–PMAA may represent a useful approach for targeting its release at its site of absorption, sustaining its release and improving its oral availability.

We also recommend Trading Suppliers and Manufacturers of METHACRYLIC ACID CALCIUM SALT (cas 16809-88-4). Pls Click Website Link as below: cas 16809-88-4 suppliers

Prev:Poly methacrylic acid modified CDHA nanocomposites as potential pH responsive drug delivery vehicles
Next:Noncollapsing polyelectrolyte conetwork gels in physiologically relevant salt solutions)