1,6-Bis[(benzyloxy)methyl]uracil derivatives—Novel antivirals with activity against HIV-1 and influenza H1N1 virus

Add time:07/11/2019    Source:sciencedirect.com

A series of 1,6-bis[(benzyloxy)methyl]uracil derivatives combining structural features of both diphenyl ether and pyridone types of NNRTIs were synthesized. Target compounds were found to inhibit HIV-1 reverse transcriptase at micro- and submicromolar levels of concentrations and exhibited anti-HIV-1 activity in MT-4 cell culture, demonstrating resistance profile similar to first generation NNRTIs. The synthesized compounds also showed profound activity against influenza virus (H1N1) in MDCK cell culture without detectable cytotoxicity. The lead compound of this assay appeared to exceed rimantadine, amantadine, ribavirin and oseltamivir carboxylate in activity. The mechanism of action of 1,6-bis[(benzyloxy)methyl]uracils against influenza virus is currently under investigation.

We also recommend Trading Suppliers and Manufacturers of 4-(([(2,4-DICHLOROBENZYL)OXY]AMINO)METHYL)-1(2H)-PHTHALAZINONE (cas 339023-37-9). Pls Click Website Link as below: cas 339023-37-9 suppliers

Prev:Diastereoselectivity in the triethylamine-catalyzed sulfa-Michael addition of thiols to nitroalkenes: kinetic and thermodynamic control
Next:Chain-growth condensation polymerization of 5-aminoisophthalic acid triethylene glycol ester to afford well-defined, water-soluble, thermoresponsive hyperbranched polyamides)