Induction by an hepatic carcinogen, 1-nitroso-5,6-dihydrouracil (cas 16813-36-8), of single and double strand breaks of liver DNA with rapid repair

Add time:07/22/2019    Source:sciencedirect.com

The nitrosoureas derived from 3 naturally occurring ureides were administered to rats and the velocity sedimentation of hepatic DNA in alkaline and neutral sucrose gradients determined. The potent hepatocarcinogen 1-nitroso-5,6-dihydrouracil induced apparent double strand as well as single strand breaks in liver DNA within 30 minutes. This damage seemed to be repaired within 4 hours. In contrast, 1-nitrosohydantoin and δ-nitroso-L-citrulline, neither of which are known hepatocarcinogens, did not modify the velocity sedimentation of hepatic DNA.

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