Reaction of 1-(oxiran-2-ylmethyl)-1H-indole-3-carboxaldehyde with amines

Add time:07/22/2019    Source:sciencedirect.com

Interaction of 1-(oxiran-2-ylmethyl)-1H-indole-3-carboxaldehyde with primary amines occurs at oxirane moiety and leads to b-aminoalcohols. Quantum-chemical calculations show that these products are more stable than possible alternative Schiff bases arising from aldehyde group of the considered bielectrophiles.

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