A convenient synthesis of N-methyl-3-(2-ethenylphenyl)-1(2H)-isoquinolones, key models for the elaboration of the benzo[c]phenanthridinone and phenanthridine skeletons

Add time:07/20/2019    Source:sciencedirect.com

A variety of N-methyl-3-(2-ethenylphenyl)-1(2H)-isoquinolones 1a–e have been prepared by base-induced intramolecular cyclization of N-(2-ethenylbenzoyl)-N,2-dimethylbenzamide derivatives 2a–e. The concomitant formation of the fused dihydro benzo[c]phenanthridinones 7a–e was also observed during this process.

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