Preparation and characterization of electrospun alginate nanofibers loaded with ciprofloxacin hydrochloride

Add time:07/15/2019    Source:sciencedirect.com

Alginate nanofibers were prepared in the presence of poly(ethylene oxide) (PEO), a surfactant Pluronic F-127, and a model drug (ciprofloxacin hydrochloride, CpHCl), all mixed prior to electrospinning. It was demonstrated that addition of a carrier polymer (PEO) and a small amount of surfactant are necessary to obtain uniform alginate fibers with cylindrical shape and regular morphology. Importantly, PEO was completely removed from the resulting nanofibers during cross-linking and stabilization post-treatment. The stable alginate fibers loaded with CpHCl were examined by scanning electron microscopy and the average diameter of the fibers ranged from 109 nm (unloaded fibers) to 161 nm (loaded fibers). The release of a studied antibiotic from the nanofibers, characterized by a final loading efficiency of 51%, was tested in physiological conditions. It was revealed that ca. 24% of CpHCl is released during first 20 h with combined transport mechanism, however with the predominant contribution of Fickian diffusion.

We also recommend Trading Suppliers and Manufacturers of 3-{6-[(2E)-3-phenylprop-2-en-1-yl]-6-azabicyclo[3.2.1]oct-1-yl}phenol hydrochloride (cas 61098-69-9). Pls Click Website Link as below: cas 61098-69-9 suppliers

Prev:Destruction of tetracycline hydrochloride antibiotics by FeOOH/TiO2 granular activated carbon as expanded cathode in low-cost MBR/MFC coupled system
Next:Antiviral activity of arbidol hydrochloride against herpes simplex virus I in vitro and in vivo)