Metabolism of 1-hydroxybenzo[a]pyrene
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Add time:07/22/2019 Source:sciencedirect.com
A metabolite of the known carcinogen benzo[a]pyrene (BP), 1-hydroxybenzo[a]pyrene 1-BPOH, is further metabolized by rat liver homogenate and microsomes. This oxidation is shown to be enzyme-catalyzed and dependent upon the presence of NADH and NADPH. Isolation of the final product yielded the BP-1,6-dione.
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