Tris(2,4,6-tribromophenoxy) dichlorophosphorane: A novel condensing agent for rapid internucleotidic bond formation in the phosphotriester approach

Add time:07/22/2019    Source:sciencedirect.com

A new class of condensing agent, tris (2,4,6-tribromophenoxy) - dichlorophosphorane (BDCP), was applied to the oligodeoxyribonucleotide synthesis. This reagent enabled us to perform a rapid internucleotidic bond formation in the phosphotriester approach only in 1 minute via an active phosphorylnitrotriazole intermediate.

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