Flueggenoids A – E, new dinorditerpenoids from Flueggea virosa

Add time:07/22/2019    Source:sciencedirect.com

A phytochemical investigation on the twigs and leaves of Flueggea virosa (Euphorbiaceae) led to the isolation of flueggenoids A – E (1–5), five new 13-methyl-ent-podocarpanes, together with eleven known compounds (6–16). Their structures and absolute configurations were elucidated on the basis of extensive MS and NMR data analysis, and/or single-crystal X-ray diffraction, time-dependent density functional theory (TDDFT)-based electronic circular dichroism (ECD) calculations, and chemical transformation. All isolates were evaluated for anti-HCV activity, the results showed that terpenoids of F. virosa had nonnegligible contribution for the anti-HCV activity.

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