Relationship between respiratory stimulant and convulsant activity of doxapram hydrochloride in conscious animals

Add time:07/23/2019    Source:sciencedirect.com

Doxapram hydrochloride was administered to unrestrained, conscious animals by continuous intravenous infusion. Respiratory stimulant and convulsant doses were recorded and a ratio of these doses was determined for each species under test. Ratios were found to be 38:1 for the cat, 10:1 for the rabbit and 11:1 for both the rat and mouse. In a comparative study, corresponding ratios obtained with ethamivan and prethcamide were notably smaller than those recorded with doxapram hydrochloride. Since the ratios of convulsant to respitory respiratory stimulant, it is concluded that doxapram hydrochloride may have a greater margin of safety in clinical use than either ethamivan or prethcamide.

We also recommend Trading Suppliers and Manufacturers of DoxapraM interMediate (cas 15083-72-4). Pls Click Website Link as below: cas 15083-72-4 suppliers

Prev:Effects of doxapram, prethcamide and lobeline on spirometric, blood gas and acid–base variables in healthy new-born calves
Next:A STUDY OF NALOXONE AND DOXAPRAM AS AGENTS FOR THE REVERSAL OF NEUROLEPTANALGESIC RESPIRATORY DEPRESSION IN THE CONSCIOUS RABBIT)