Analytical Profile of nalorphine hydrobromide (cas 1041-90-3)

Add time:07/22/2019    Source:sciencedirect.com

Publisher SummaryThis chapter discusses the analytical profile of nalorphine hydrobromide. Its generic names are allorphine, anarcon, antrophine, lethidrone, nalline, and norfin. It is an odorless, white to creamy white crystalline powder. Its melting range is about 260° with decomposition. It is soluble in 24 parts of water and in 35 parts of 95% ethanol. Aqueous solutions may deposit crystals of the dihydrate. The hydrated form is readily soluble in dehydrated ethanol, and the solutions rapidly give rise to a deposit of the anhydrous form. Solid state conformation of nalorphine hydrobromide, morphine and naloxone has also been compared by measuring their torsion angles. The infrared spectrum of nalorphine hydrobromide as KBr disc is shown in the chapter. The PMR spectrum of nalorphine hydrobromide in deuterated dimethylsulfoxide was recorded on a Varian T60A 60 MHz nuclear magnetic resonance (NMR) spectrometer, using tetramethylsilane (TMS) as an internal standard.

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