Total synthesis of proinflammatory dihydro-12-KETE metabolites

Add time:07/23/2019    Source:sciencedirect.com

The first total synthesis of the 10,11-dihydro-12-ketoeicosatetraenoic acid (10,11-dihydro-12-KETE) 5, a proinflammatory metabolite of 12-KETE is reported. In addition, the total synthesis of two other potential metabolites of 12-KETE, namely 8,11-dihydro-12-KETE 6 and 8,9-dihydro-12-KETE 7, is also described. These three synthetic compounds are aimed at investigating a new biosynthetic reductive pathway for 12-hydroxyeicosatetraenoic acid (12-HETE) and 12-KETE.

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