Potential coenzyme inhibitors—V1

Add time:07/22/2019    Source:sciencedirect.com

The chemical synthesis of 4-methylnicotinamide adenine dinucleotide from 3-carbamoyl-1-(2,3-O-isopropylidine-d-ribofuranosyl)-4-methyl pyridinium chloride is presented, and some properties of the modified coenzyme are described with particular reference to its potential as a cofactor for the glycolytic sequence in neoplastic cells. The compound was found to be amenable to chemical 1,4-reduction, to be capable of binding to glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12), and to act as a competitive inhibitor to nicotinamide adenine dinucleotide in the conversion of d-glyceraldehyde-3-phosphate to 1,3-diphospho-d-glycerate catalysed by this enzyme.

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