Reduction of 4-Hydroxynonenal and 4-hydroxyhexenal (cas 109710-37-4) by Retinal Aldose Reductase

Add time:07/26/2019    Source:sciencedirect.com

Aldose reductase has been purified to homogeneity from bovine retina. It has an apparent molecular weight of 32,000 daltons and shares immunological and kinetic properties with the much studied aldose reductases purified from various sources. Retinal aldose reductase displays aKmof approximately 40 μM with 4-hydroxynonenal and 4-hydroxyhexenal (cas 109710-37-4), the oxidation end products of arachidonic and docosahexanoeic acids, respectively. It therefore appears that aldose reductase may constitute a major detoxification route of these toxic aldehydes in the retina.

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