Baylis-Hillman acetates in organic synthesis: A simple two-step strategy for oxindole-spiro-α-arylidene-γ-butyrolactone framework
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Add time:07/22/2019 Source:sciencedirect.com
A facile, convenient, and two step strategy for synthesis of spirooxindoles containing α-arylidene-γ-butyrolactone moiety has been developed via monoalkylation of 2-oxindoles with Baylis-Hillman acetates followed by the spirolactonization of the resulting cinnamic esters on treatment with phenyliodine (III) bistrifluoroacetate (PIFA).
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