Synthesis of novel monostyryl and distyryl boron dipyrromethenes bearing 4-((2-hydroxyethyl)(methyl)amino group as cholinesterase and tyrosinase inhibitors

Add time:07/23/2019    Source:sciencedirect.com

In this study, the synthesis of novel Monostyryl and Distyryl boron dipyrromethene dyes containing 4-((2-hydroxyethyl)(methyl)amino) group to determine neuroprotective potential has been reported for the first time. They were synthesized starting from BODIPY dye 1. Their inhibitory properties against Acetylcholinesterase/Butyrylcholinesterase (AChE/BuChE) and tyrosinase (Tyr) were evaluated according to Ingkaninan’s and Masuda’s methods and kinetic analysis of compounds was done using Lineweaver-Burk and Dixon plots.

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