Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate

Add time:07/24/2019    Source:sciencedirect.com

A method is described for labeling proteins with 7.2 h half-life 211At. The α particle-emitting nuclide was coupled to goat IgG using an N-succinimidyl 3-(tri-n-butylstannyl) benzoate intermediate. The reaction and purification sequence requires about 2 h to produce 211At-labeled IgG in 25–40% radiochemical yield. Comparative blood clearance measurements in mice suggest that the 211At-labeled IgG conjugate is stable in vivo.

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