Propranolol blocks the tachycardia induced by galanin (1–15) but not by galanin (1–29)

Add time:07/23/2019    Source:sciencedirect.com

The efferent pathways involved in the tachycardia induced by intracisternal injections of the N-terminal galanin fragment (1–15) (GAL (1–15)) and galanin (GAL (1–29)) has been evaluated in rats pretreated with the cholinergic antagonist atropine or the β-antagonist propranolol. The pretreatment with propranolol significantly blocked the tachycardic and vasopressor effect produced by intracisternal injection of GAL (1–15) (p<0.05), but the pretreatment with atropine did not modify these cardiovascular effects. However, the cardiovascular response elicited by GAL (1–29) is modified by the pretreatment with atropine (p<0.05) but not by propranolol. These findings demonstrate that the central cardiovascular action of GAL (1–15), but not GAL (1–29), is mediated by β-receptor stimulation and this suggests the existence of a different pathway involved in the cardiovascular response produced by the N-terminal galanin fragment as compared with the parent molecule GAL (1–29).

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