Enantioselective solution- and solid-phase synthesis of glutamic acid derivatives via Michael addition reactions

Add time:07/23/2019    Source:sciencedirect.com

The enantioselective conjugate addition of Schiff base ester derivatives to Michael acceptors either in solution (56–89% e.e.) or on solid-phase (34–82% e.e.) gave optically active unnatural α-amino acid derivatives. The reaction was conducted in the presence of chiral, non-racemic quaternary salts derived from the cinchona alkaloids using neutral, non-ionic phosphazene bases.

We also recommend Trading Suppliers and Manufacturers of 7-[(PHENYLSULFONYL)AMINO]HEPTANOIC ACID (cas 123469-53-4). Pls Click Website Link as below: cas 123469-53-4 suppliers

Prev:Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human
Next:Synthesis, biological activity and structure–activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells)