Racemic and optically active 2-methoxy-4-oxatetradecanoic acids: novel synthetic fatty acids with selective antifungal properties

Add time:07/29/2019    Source:sciencedirect.com

The unprecedented (±)-2-methoxy-4-oxatetradecanoic acid and the optically pure (S)-2-methoxy-4-oxatetradecanoic acid were synthesized in six steps and in 11–14% overall yields starting with either 1,2-O-isopropylidene-rac-glycerol or 1,2-O-isopropylidene-(S)-glycerol. The key step in the synthesis was the selective monosilylation of a dibutylstannylene intermediate. The title compounds displayed selective fungitoxicity in the range of 0.08–0.22 mM against Cryptococcus neoformans ATCC 66031 and Aspergillus niger ATCC 16404, but no significant activity against C. albicans ATCC 14053 and ATCC 60193 (>2.6 mM). Albeit being good substrates for N-myristoyltransferases (NMTs), the racemic and the S-enantiomer of the oxygenated 2-methoxylated compounds showed no significant difference in antifungal activity. This finding suggests an alternative mechanism of fungitoxicity other than NMT inhibition.

We also recommend Trading Suppliers and Manufacturers of 4-[4-(Decyloxy)-3-fluorophenyl]-benzoic acid (cas 106291-00-3). Pls Click Website Link as below: cas 106291-00-3 suppliers

Prev:A highly versatile stable optical sensor based on 4-decyloxy-2-(2-pyridylazo)-1-naphthol in Nafion for the determination of copper
Next:4-tert-butylcalix[4]arene having nitrile pendant groups as Hg2+ selective receptors)