Glycosyl-inositol derivatives

Add time:07/25/2019    Source:sciencedirect.com

The disaccharides related to glycosyl phosphatidyl Inosltol anchors of membrane proteins, 4-O-(2-amino-2-deoxy-α-D-glucopyranosyl)-D-myo-inositol-1-phosphate and 4-O-(2amino-2-deoxy-α-D-galactopyranosyl)-D-chiro-inositol-1-phosphate, have been prepared from optically resolved myo-inosltol derivatives. The chiro-inositol moiety was obtained by epimerlzatlon of a selectively blocked myo-inositol-trifiate ester. The resolved inositols were subsequently phosphoryiated to yield the disaccharide aglycones. The amino-sugar components were prepared by azidonitratlon of suitably protected glucal and galactal derivatives. The derived pyranosyl chlorides were then condensed with the inositol phosphates using silver triflate as the promoter.

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