Total synthesis of lithospermic acid using Fe-catalyzed Cross-Dehydrogenative-Coupling reaction and Pd-catalyzed ester-directed CH olefination

Add time:07/23/2019    Source:sciencedirect.com

The total synthesis of lithospermic acid has been accomplished employing two CH activation reactions as key steps. Fe-catalyzed Cross-Dehydrogenative-Coupling reaction was used for the rapid construction of benzofuran framework. Pd-catalyzed ester-directed CH olefination allowed the efficient assembly of the dihydrobenzofuran ester and acrylate moieties.

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