Bunazosin hydrochloride reduces glutamate-induced neurotoxicity in rat primary retinal cultures

Add time:07/25/2019    Source:sciencedirect.com

To study neuroprotective effects of bunazosin hydrochloride which is an α1-adrenoceptor antagonist used as an ocular hypotensive drug compared to other α1-adrenoceptor antagonists, and its mechanism of action. We evaluated the neuroprotective effects of bunazosin hydrochloride or seven other α1-adrenoceptor antagonists against glutamate-induced cell death in rat primary retinal cultures. We also evaluated the binding inhibition of bunazosin hydrochloride for 24 different receptors/channels and its effects on the Na+ influx into cells induced by veratridine or glutamate. Bunazosin hydrochloride significantly inhibited glutamate-induced cell death at concentrations of 1 and 10 μM. Cells were also protected when treated with some α1-adrenoceptor antagonists, but not by the others. Bunazosin hydrochloride showed a high inhibition for Na+ channels and inhibited the Na+ influx induced by veratridine or glutamate. These findings indicate that in retinal cultures bunazosin hydrochloride has a neuroprotective effect against glutamate-induced cell death and that the inhibition of Na+ channels by bunazosin hydrochloride may be partly responsible for this effect.

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