Eco-friendly synthesis of 3-etherified estrones
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Add time:07/31/2019 Source:sciencedirect.com
The conventional etherification uses toxic or hardly degradable alkylating agents. An eco-friendly tandem etherification/aromatization is presented to prepare estrone 3-secondary ethers from easily available dienone 1. Three marketed 3-etherified estrogen drugs were synthesized with the method from commercial available starting material.
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