Synthesis and reduction reactions of pyridones and 5-acyl-2-Methoxypyridine (cas 1628-89-3)s
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Add time:07/26/2019 Source:sciencedirect.com
The synthesis of a series of pyridones, from their 2-hydroxypyridine or 2-methoxypyridine precursors, is described, along with studies into their reductions to saturated heterocycles. A number of 5-acylpyridones were prepared and were evaluated as substrates for asymmetric transfer hydrogenation prior to conversion to saturated heterocycles. The enantioselective reduction of 5-acetyl-1-benzylpyrimidine-2,4(1H,3H)-dione is also described.
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