Evaluation of cystamine-modified hyaluronic acid/chitosan polyplex as retinal gene vector
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Add time:07/27/2019 Source:sciencedirect.com
PurposeA successful gene therapy approach can prevent or treat congenital and acquired diseases. However, there is still no ideal non-viral vector for gene delivery in a safe and timely manner. In this report the anionic polymer hyaluronic acid (HA) was investigated as a potential vector for gene therapy. Due to its intrinsic characteristics it constitutes an excellent candidate to deliver therapeutic genes, pending the modification of its surface charge.
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