Hyaluronic acid based hydroxamate and conjugates with biologically active amines: In vitro effect on matrix metalloproteinase-2

Add time:07/25/2019    Source:sciencedirect.com

In this study, water soluble hyaluronic acid (HA) based hydroxamate and conjugates with biologically active amines and hydrazides such as p- and o-aminophenols, anthranilic, 4- and 5-aminosalicylic acids, nicotinic, N-benzylnicotinic and isonicotinic hydrazides, p-aminobenzenesulfonamide (Streptocide), p-aminobenzoic acid diethylaminoethyl ester (Procaine), and 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one (4-aminoantipyrene) were examined as matrix metalloproteinase-2 inhibitors (MMPIs). In a dose of 0.27–270 μM, the most efficient MMPIs were HA conjugates with o-aminophenol = 4-aminoantipyrine > 4-aminosalicylic acid > 5-aminosalicylic acid. Conjugates with Streptocide, Procaine and HA hydroxamate showed 40–50% inhibitory effect at all used concentrations. Conjugates with anthranilic acid and isonicotinic hydrazide (Isoniazid) in a dose of 0.27 μM inhibited enzyme activity by ∼70%, but with the concentration increase their inhibitory effect was decreased.

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