Intramolecular N-aza-amidoalkylation in association with Witkop–Winterfeldt oxidation as the key step to synthesize Luotonin-A analogues
-
Add time:07/27/2019 Source:sciencedirect.com
An expedient four-step approach for the synthesis of a short library of original analogues of the Topo-I Luotonin-A inhibitor, substituted at their C8- and N15-positions, was investigated. This consists of Rutaecarpines formation, their Witkop–Winterfeldt oxidation followed ultimately with functional adjustment of the pyrroloquinolone intermediates. In the first step of these investigations, Rutaecarpines including the Topo-I poison Evodiamine were obtained via the new tandem N-acylation/aza-amidoalkylation using a nitrogen atom as an internal nucleophile with or without association with a decarboxylation.
We also recommend Trading Suppliers and Manufacturers of 3-(AZA(PHENYLAMINO)METHYLENE)-1-METHYLINDOLIN-2-ONE (cas 15096-16-9). Pls Click Website Link as below: cas 15096-16-9 suppliers
Prev:Lewis acid-catalyzed reactions of N-allylanilines with diazo compounds involving aza-Claisen rearrangement
Next:New efficient synthesis of pyrimido[1,6-c]quinazolin-4-ones by a Biginelli 3CC/Staudinger/aza-Wittig sequence) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Antibacterial 3-(arylamino)-1-ferrocenylpropan-1-ones: Synthesis, spectral, electrochemical and structural characterization07/29/2019
- New efficient synthesis of pyrimido[1,6-c]quinazolin-4-ones by a Biginelli 3CC/Staudinger/aza-Wittig sequence07/28/2019
- Lewis acid-catalyzed reactions of N-allylanilines with diazo compounds involving aza-Claisen rearrangement07/26/2019
- A domino Kornblum-DeLaMare/aza-Michael reaction of 3,6-dihydro-1,2-dioxines and application to the synthesis of the ceramide transport inhibitor (±)-HPA-1207/25/2019
- A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines07/24/2019
