Reaction des acyloxy-2 chloro-3 chloromethyl-2 propanamides avec l'hydroxyde de potassium ou le fluorure de cesium en milieu heterogene synthese de spiro β-lactames

Add time:07/24/2019    Source:sciencedirect.com

The reaction of cesium fluoride with the 2-acyloxy 3-chloro 2-chloromethylpropanamides (4) gave the 3-acyloxy 3-chloromethyl azetidine 2-ones (6) . Treated by powdered potassium hydroxide, 4 and 6 were converted into the 1-oxa 4-oxo 5-aza spiro (2,3) hexanes. These reactions in heterogeneous media were very selective and gave excellent yields.

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