Concise synthesis of binaphthol-derived chiral dicarboxylic acids

Add time:07/26/2019    Source:sciencedirect.com

3,3′-Disubstituted 1,1′-binaphthyl-2,2′-dicarboxylic acids (1) were synthesized in three or four steps from commercially available BINOL via carbon dioxide fixation with organolithium to incorporate the carboxylic acid moieties, followed by either carboxylate-directed ortho-C–H arylation or Suzuki cross-coupling. This method provides easy access to various types of axiially chiral dicarboxylic acids, which should be useful for studies of chiral Brønsted acid-catalyzed asymmetric reactions.

We also recommend Trading Suppliers and Manufacturers of 2-METHYLNAPHTHALENE-1-BORONIC ACID (cas 103989-84-0). Pls Click Website Link as below: cas 103989-84-0 suppliers

Prev:Pd(II) complexes of monodentate deoxycholic acid derived binaphthyl diamido phosphites as chiral catalysts in the asymmetric Suzuki-Miyaura cross-coupling
Next:Catalytic decomposition of polystyrene. The role of acid and basic active centers)