Determination of Sulfamonomethoxine (cas 1220-83-3) in tilapia (Oreochromis niloticus × Oreochromis mossambicus) by liquid chromatography-tandem mass spectrometry and its application pharmacokinetics study
-
Add time:07/28/2019 Source:sciencedirect.com
A precise and reliable analytical method to measure trace levels of Sulfamonomethoxine (cas 1220-83-3) (SMM) and N4-acetyl metabolite in tilapia samples using liquid chromatography-tandem mass spectrometry was developed. Optimized chromatographic separation was performed on C18 reversed-phase columns using gradient elution with methanol and 5 mmol/L of an ammonium acetate aqueous solution (adjusted to pH 3.5 using formic acid). This study investigated the pharmacokinetic properties and tissue distribution of SMM and its major metabolite N4-acetyl sulfamonomethoxine (AC-SMM) in tilapia after a single dose of 100 mg kg−1 body weight of orally administered SMM. Blood and tissues were collected between 0.5 and 192 h with 14 total sampling time points. SMM was rapidly absorbed, and extensively distributed in the bile and liver through systemic circulation. Enterohepatic circulation of SMM was observed in the tilapia body. Acetylation percentages were 45% (blood), 90% (liver), 62% (kidney), 98% (bile), and 52% (muscle). High concentrations of AC-SMM accumulated in the tilapia bile. At 192 h, AC-SMM concentration in the bile remained at 4710 μg kg−1. The ke value of AC-SMM (0.015 h−1) in the blood was lower than that of SMM (0.032 h−1). This study demonstrated effective residue monitoring and determined the pharmacokinetic properties of SMM and AC-SMM in tilapia.
We also recommend Trading Suppliers and Manufacturers of Sulfamonomethoxine (cas 1220-83-3). Pls Click Website Link as below: cas 1220-83-3 suppliers
Prev:Quantitative analysis of weak interactions by Lattice energy calculation, Hirshfeld surface and DFT studies of Sulfamonomethoxine (cas 1220-83-3)
Next:Physiological and behavioral responses in offspring mice following maternal exposure to Sulfamonomethoxine (cas 1220-83-3) during pregnancy) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Degradation of Sulfamonomethoxine (cas 1220-83-3) with Fe3O4 magnetic nanoparticles as heterogeneous activator of persulfate08/03/2019
- Synthesis, spectral and quantum chemical studies on NO-chelating Sulfamonomethoxine (cas 1220-83-3)–cyclophosph(V)azane and its Er(III) complex08/02/2019
- Removal behaviors of Sulfamonomethoxine (cas 1220-83-3) and its degradation intermediates in fresh aquaculture wastewater using zeolite/TiO2 composites08/01/2019
- Surface charge modification of chloromethylated polystyrene beads with NaH for the removal of Sulfamonomethoxine (cas 1220-83-3)07/31/2019
- Distribution of Sulfamonomethoxine (cas 1220-83-3) and trimethoprim in egg yolk and white07/30/2019
- Physiological and behavioral responses in offspring mice following maternal exposure to Sulfamonomethoxine (cas 1220-83-3) during pregnancy07/29/2019
- Quantitative analysis of weak interactions by Lattice energy calculation, Hirshfeld surface and DFT studies of Sulfamonomethoxine (cas 1220-83-3)07/27/2019
- Toxicity of the veterinary sulfonamide antibiotic Sulfamonomethoxine (cas 1220-83-3) to five aquatic organisms07/26/2019
- Using ionic liquid monomer to improve the selective recognition performance of surface imprinted polymer for Sulfamonomethoxine (cas 1220-83-3) in strong polar medium07/25/2019
-
Health and Chemical more >
-
Related Products