Comparative Assays for Doxepin and DESMETHYLDOXEPIN (cas 1225-56-5) Using High-Performance Liquid Chromatography and High-Performance Thin-Layer Chromatography

Add time:07/29/2019    Source:sciencedirect.com

□ Two chromatographic methods, high-performance liquid chromatography (HPLC) and high-performance thin-layer chromatography (HPTLC) were compared for sensitivity and reproducibility in the analysis of the tricyclic antidepressant doxepin and its metabolite, DESMETHYLDOXEPIN (cas 1225-56-5), in plasma. The HPLC procedure yielded a better reproducibility, as reflected by the coefficient of variation, and a higher sensitivity, as reflected by the minimum detectable quantity. The application of these methods for therapeutic and subtherapeutic monitoring of plasma levels of the drug is described.

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