Dopamine enhancement of dextrorphan-induced skin antinociception in response to needle pinpricks in rats

Add time:07/25/2019    Source:sciencedirect.com

BackgroundDextrorphan with long-acting local anesthetic effects did not cause system toxicity as fast as bupivacaine, while catecholamines (i.e., epinephrine) with the vasoconstrictive characteristics enhanced the effects of local anesthetic drugs. The objective of the experiment was to examine the synergistic effect of local dopamine (a catecholamine) injection on cutaneous antinociception of dextrorphan.

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