Validation of two fluoro-analogues of N,N-dimethyl-2-(2′-amino-4′-hydroxymethyl-phenylthio)benzylamine as serotonin transporter imaging agents using microPET

Add time:07/25/2019    Source:sciencedirect.com

IntroductionCarbon-11 (C-11) N,N-dimethyl-2-(2′-amino-4′-hydroxymethyl-phenylthio)benzylamine ([11C]HOMADAM) has been reported as highly specific and selective positron emission tomography (PET) radiotracer showing fast kinetics for the human brain serotonin transporter (SERT). In our continued effort to develop appropriate PET SERT radioligand that can be labeled with either C-11 or fluorine-18 (F-18), two new C-11 labeled analogues of HOMADAM, [11C]-N,N-dimethyl-2-(2′-amino-5′-fluoro-4′-hydroxymethyl-phenylthio)benzylamine ([11C]-(2)) and [11C]-N,N-dimethyl-2-(2′-amino-4-fluoro-4′-hydroxymethyl-phenylthio)benzylamine ([11C]-(3)) have been synthesized and evaluated along the previously reported [11C]-N,N-dimethyl-2-(2′-amino-5-fluoro-4′-hydroxymethyl-phenylthio)benzylamine ([11C]-(1)).

We also recommend Trading Suppliers and Manufacturers of ETHYL FLUORO(PHENYLTHIO)ACETATE (cas 106372-59-2). Pls Click Website Link as below: cas 106372-59-2 suppliers

Prev:Simultaneous determination of acesulfame-K and aspartame using linear sweep voltammetry and multivariate calibration
Next:Synthesis of novel GABA uptake inhibitors. part 6†: Preparation and evaluation of N-Ω asymmetrically substituted nipecotic acid derivatives)