pH-controlled doxorubicin delivery from PDEAEMA-based nanogels

Add time:07/27/2019    Source:sciencedirect.com

In this work, the feasibility of some poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA)-based pH-sensitive nanogels as drug nanocarriers is evaluated. The anticancer drug doxorubicin (DOXO) is successfully encapsulated into the nanogels, achieving high drug loading and encapsulation efficiency. It has been found that the in vitro delivery of DOXO from the nanogels was pH-dependent: DOXO release rate is accelerated by decreasing pH from 7.4 (healthy cells) to 5.2 (pH condition for endo/lysosomial compartments and unhealthy cells) due to the swelling of the nanogel particles. The uptake of DOXO-loaded nanogels into MDA-MB-231 tumoral cells and the progressive release of the drug from the nanogels to the cell nuclei are demonstrated by fluorescence microscopy measurements. These results suggest a great potential of these DOXO-loaded nanogels for antitumor drug delivery.

We also recommend Trading Suppliers and Manufacturers of Doxorubicin IMpurity B (cas 106401-68-7). Pls Click Website Link as below: cas 106401-68-7 suppliers

Prev:Inverse-Micelle Synthesis of Doxorubicin-Loaded Alginate/Chitosan Nanoparticles and In Vitro Assessment of Breast Cancer Cytotoxicity
Next:Effective doxorubicin-based nano-therapeutics for simultaneous malignant lymphoma treatment and lymphoma growth imaging)