Heterocyclizations of 2-aryl-3-arylamino-4,4,4-trifluoro-2-butenenitrile hydrates to 3-aryl-2-trifluoromethyl-4-quinolones and to 4-N-methylamino-3H-pyrazole-3-spiro-2′-(3′-aryl-3′-trifluoromethyl)oxiranes

Add time:07/28/2019    Source:sciencedirect.com

2-Aryl-3-arylamino-4,4,4-trifluoro-2-butenenitriles were obtained as hydrates from 3-oxo-2-aryl-4,4,4-trifluorobutyronitriles and anilines and their structure and heterocyclizations studied. Cyclization with polyphosphoric acid gave poor yields of 3-aryl-2-trifluoromethyl-4-quinolones, but they underwent an interesting cyclization with diazomethane to give a 25%–40% yield of 4-N-methylamino-3H-pyrazole-3-spiro-2′-(3′-aryl-3′-trifluoromethyl)oxiranes. However, the related reaction with diazoethane yielded only aryl(arylhydrazono)acetonitriles and other fragmentation products.

We also recommend Trading Suppliers and Manufacturers of 2-(N-ethyl-p-toluidino)ethanol (cas 13386-60-2). Pls Click Website Link as below: cas 13386-60-2 suppliers

Prev:Synthesis and in-vitro anticancer activity of 3-cyano-6,9-dimethyl-4-imino 2-methylthio 4H-pyrimido [2,1-b] [1,3] benzothiazole and its 2-substituted derivatives
Next:Antitumor studies. Part 5: Synthesis, antitumor activity, and molecular docking study of 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins)