Conjugates of platinum nanoparticles with gallium tetra – (4-Carboxyphenyl) porphyrin and their use in photodynamic antimicrobial chemotherapy when in solution or embedded in electrospun fiber

Add time:07/11/2019    Source:sciencedirect.com

The conjugation of Pt nanoparticles with ClGa(III) 5,10,15,20-tetrakis-(4-carboxyphenyl) porphyrin (ClGaTCPP) showed greater antimicrobial activity against a gram positive and drug resistant bacteria Staphylococcus aureus, than when the porphyrin was used alone. ClGaTCPP and its conjugate with platinum nanoparticle was successfully electrospun into a polystyrene polymer where the diameter ranged from 10 to 22 μm. The conjugates within the fiber still showed activity towards S. aureus.

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