Induction of the homeotic gene Hoxa1 through valproic acid's teratogenic mechanism of action

Add time:07/26/2019    Source:sciencedirect.com

BackgroundValproic acid (VPA) exposure in utero has been associated with an increased risk of both neural tube defects and autism spectrum disorders (ASDs). The terata induced by VPA suggest interference with pattern formation. Retinoic acid produces similar terata and is known to act in part by increasing the expression of Hoxa1. We tested the hypotheses that exposure to VPA would alter the expression of Hoxa1 in rat embryos during times of normal Hoxa1 expression (d10.5–13.5) and that exposure at earlier and later stages would induce inappropriate expression.

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