Carcinogenicity and nephrotoxicity of 2-amino-, 1-amino- 2-methyl-, and 2-methyl-1-nitro-anthraquinone

Add time:07/28/2019    Source:sciencedirect.com

2-Aminoanthraquinone (AA), l-amino-2-methylanthraquinone (l-Am-2-MeA), and 2-methyl-l-nitroanthraquinone (2-Me-1-Na) were tested for carcinogenicity in Fischer 344 rats and B6C3F1 mice. In rats, all the 3 chemicals increased the incidence of hepatocellular neoplasms. Renal neoplasms were increased with 1-Am-2-MeA, and 2-Me-1-NA increased the incidence of subcutaneous fibromas in a dose-related manner. In mice, incidences of hepatocellular carcinomas were increased with feeding of AA, and 2-Me-l-NA increased the incidence of subcutaneous hemangiosarcomas. 1-Am-2-MeA did not appear to be carcinogenic in the mouse. Nephrotoxicity was associated with feeding of AA to female rats and 1-Am-2-MeA to mice.

We also recommend Trading Suppliers and Manufacturers of 2-amino-1-nitroanthraquinone (cas 10262-82-5). Pls Click Website Link as below: cas 10262-82-5 suppliers

Prev:A new method for the preparation of 1-amino-4-bromo-2-anthraquinonesulphonic acid (bromamine acid) directly from anthraquinone
Next:Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors)