High-performance liquid chromatographic analysis of the antituberculosis drugs Aconiazide (cas 13410-86-1) and isoniazid

Add time:07/27/2019    Source:sciencedirect.com

Reversed-phase HPLC methods are described for determining the stability and concentration certification of the antituberculosis prodrug Aconiazide (cas 13410-86-1) (ACON) in aqueous dosing solution and for assessing the concentrations of ACON and isoniazid (INH) in plasma from ACON-treated male and female Fischer-344 rats. ACON was analyzed in plasma by direct injection; it was separated on a 250 × 4.6 mm I.D. 5 μm C18 column using a 40% aqueous methanol mobile phase containing 5 g/l ammonium formate, and detected at 313 nm. INH was determined in the plasma of treated rats after a two-step precipitation of plasma proteins; it was separated on a 250 mm × 4.6 mm I.D. 5 μm CN column, eluted with 5% aqueous isopropanol containing 5 g/l ammonium formate, and detected with an electrochemical detector at +0.8 V. These methods allow a simple, rapid, and reliable determination of ACON and INH in plasma down to 0.1 μg/ml.

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