Rh2(OAc)4 and InCl3 co-catalyzed diastereoselective trapping of carbamate ammonium ylides with aldehydes for the synthesis of β-hydroxyl-α-amino acid derivatives
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Add time:07/26/2019 Source:sciencedirect.com
A Rh2(OAc)4 and InCl3 co-catalyzed three component reaction of diazo compounds, carbamates and aldehydes has been developed to synthesize β-hydroxyl-α-amino acid derivatives in good yields with excellent diastereoselectivity. The reaction is proceeded via trapping of active carbamate ammonium ylide intermediates by aromatic aldehydes.
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