pH-responsive ultrasonic self-assembly SPINOSAD (cas 131929-60-7)-loaded nanomicelles and their antifungal activity to Fusarium oxysporum

Add time:07/27/2019    Source:sciencedirect.com

In this paper, we synthesized amphiphilic chitosan using one-pot method with the goal to develop delivery system for the natural pesticide spinosad. Chitosan-Isoleucine-Polyethylene glycol methyl ether (CIP) copolymers based nanomicelles (CIPNMs) were prepared by self-assembly with the assistance of ultrasonic treatment and then the spinosad was loaded on the micelles. Sphere-shaped spinosad-loaded CIPNMs ([email protected]) with the particle sizes of approximately 454.9 nm were obtained with the CIP co-polymers. The shell of CIPNMs could effectively prevent the photodegradation of spinosad and played a role of protective barrier. In addition, the prepared [email protected] not only delayed the release of spinosad but also had a property of pH-responsive. The release rate of [email protected] at pH = 6.4 was greater than that of at pH = 7.0. And, the contact angle of [email protected] on banana leaves surface was 60.47°, which meant [email protected] had a good affinity with banana leaves. Furthermore, [email protected] showed higher antifungal activity against Fusarium oxysporum compared with the unencapsulated spinosad at the same drug dose. This work was contribution to the development of nano-drug carrier systems of natural polymer materials, with a great potential for targeted treatment of banana wilt.

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