The indoleacetic acids in IMCRs: a three-component Ugi reaction involving TosMIC

Add time:07/26/2019    Source:sciencedirect.com

Isocyanide-based MCRs (IMCRs) involving for the first time the biological and pharmaceutical active indoleacetic acids are studied. In particular, the catalytic behavior of 2-acetyl-indoleacetic acid in the Ugi three-component reaction with TosMIC is emphasized. The reaction was optimized, revealing the catalytic role of aromatic carboxylic acids as well, yielding a small library of a-aminoamides. Full assignment of all 1H and 13C NMR chemical shifts has been unambiguously achieved.

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